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MUSETTE Trial Confirms Optimal Dosing of Ocrelizumab for Relapsing MS
04/10/2025
Danielle Sposato
In a recent press release, Genentech has announced results from the phase 3 MUSETTE trial (NCT04544436), which evaluated higher doses of intravenous (IV) ocrelizumab (Ocrevus) in patients with relapsing multiple sclerosis (RMS).
In a recent press release, Genentech has announced results from the phase 3 MUSETTE trial (NCT04544436), which evaluated higher doses of intravenous (IV) ocrelizumab (Ocrevus) in patients with relapsing multiple sclerosis (RMS).
In a recent press release,...
04/10/2025
First Report Managed Care
News
Autoimmune Disease Impact on Health and Productivity of US Employees
03/26/2025
Grace Taylor, MS, MA
Chronic autoimmune conditions are emerging as a major, underrecognized burden on employers, driving up health care costs and disability claims across the US workforce.
Chronic autoimmune conditions are emerging as a major, underrecognized burden on employers, driving up health care costs and disability claims across the US workforce.
Chronic autoimmune conditions...
03/26/2025
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News
Study Finds Limited Benefit of Common MS Fatigue Medications
03/12/2025
Grace Taylor, MS, MA
Commonly used medications for multiple sclerosis-related fatigue offer minimal clinical benefit and are more likely to cause treatment discontinuation due to side effects, according to a systematic review and meta-analysis published in...
Commonly used medications for multiple sclerosis-related fatigue offer minimal clinical benefit and are more likely to cause treatment discontinuation due to side effects, according to a systematic review and meta-analysis published in...
Commonly used medications for...
03/12/2025
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News
Long COVID Symptoms Persist in Individuals With Multiple Sclerosis, Study Finds
02/10/2025
Lisa Kuhns, PhD, MD
Individuals with multiple sclerosis (MS) experience an ongoing impact of post-COVID-19 symptoms, revealing a significant overlap between post-acute sequelae of SARS-CoV-2 infection (PASC) and MS-related symptoms.
Individuals with multiple sclerosis (MS) experience an ongoing impact of post-COVID-19 symptoms, revealing a significant overlap between post-acute sequelae of SARS-CoV-2 infection (PASC) and MS-related symptoms.
Individuals with multiple...
02/10/2025
First Report Managed Care
News
Patient-Reported Outcomes Drive Value-Based Care in Multiple Sclerosis
01/13/2025
Juliet Gallagher
A recent study published in Journal of Managed Care & Specialty Pharmacy explored multiple sclerosis (MS) as a compelling therapeutic area for outcomes-based agreements (OBAs) by assessing the use of patient-reported disability progression to...
A recent study published in Journal of Managed Care & Specialty Pharmacy explored multiple sclerosis (MS) as a compelling therapeutic area for outcomes-based agreements (OBAs) by assessing the use of patient-reported disability progression to...
A recent study published in...
01/13/2025
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News
Study Suggests Cognitive Impairment More Likely With Late-Onset Multiple Sclerosis
12/19/2024
Jolynn Tumolo
Patients with late-onset multiple sclerosis (MS) performed worse on most classic and social cognitive domains than patients with adult-onset MS after accounting for patient age and disease duration.
Patients with late-onset multiple sclerosis (MS) performed worse on most classic and social cognitive domains than patients with adult-onset MS after accounting for patient age and disease duration.
Patients with late-onset...
12/19/2024
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News
Meta-Analysis Finds More Arterial Stiffness in Patients With MS
12/13/2024
Jolynn Tumolo
Patients with multiple sclerosis (MS) have significantly worse vascular function, particularly greater arterial stiffness, compared with healthy controls.
Patients with multiple sclerosis (MS) have significantly worse vascular function, particularly greater arterial stiffness, compared with healthy controls.
Patients with multiple sclerosis...
12/13/2024
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News
Using Deep Learning to Measure MS-Specific Brain Damage Beyond Aging
11/11/2024
Juliet Gallagher
A new study published in Neurology aimed to differentiate age-related brain changes from multiple sclerosis (MS)-specific neurodegeneration using MRI.
A new study published in Neurology aimed to differentiate age-related brain changes from multiple sclerosis (MS)-specific neurodegeneration using MRI.
A new study published in...
11/11/2024
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News
Impact of Immune Checkpoint Inhibitors on Multiple Sclerosis Treatment Outcomes
10/29/2024
Grace Taylor, MS, MA
Relapses and progression of multiple sclerosis were rare in patients treated with immune checkpoint inhibitors, according to a study presented at the American Academy of Neurology 2024 Annual Meeting.
Relapses and progression of multiple sclerosis were rare in patients treated with immune checkpoint inhibitors, according to a study presented at the American Academy of Neurology 2024 Annual Meeting.
Relapses and progression of...
10/29/2024
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News
Transcriptional Signatures of Multiple Sclerosis May Explain Female-Biased Gene Expression
10/29/2024
A study presented at the American Academy of Neurology 2024 Annual Meeting identified distinct transcriptional signatures in multiple sclerosis (MS) that may explain its higher prevalence in females.
A study presented at the American Academy of Neurology 2024 Annual Meeting identified distinct transcriptional signatures in multiple sclerosis (MS) that may explain its higher prevalence in females.
A study presented at the...
10/29/2024
First Report Managed Care

Behind the Bill

Behind the Bill
The Medicare Paradox: How Tariffs Could Undermine IRA Drug Pricing Reforms
04/23/2025
Katie Hayes, MJ
The Trump administration's recent announcement of national security investigations into pharmaceutical imports has set up a potential collision course with one of the most significant health care reforms in recent years. While the White...
The Trump administration's recent announcement of national security investigations into pharmaceutical imports has set up a potential collision course with one of the most significant health care reforms in recent years. While the White...
The Trump administration's...
04/23/2025
First Report Managed Care
Behind the Bill
The Bitter Pill, Now in Motion: Pharma Tariffs Move from Rhetoric to Reality
04/16/2025
Katie Hayes, MJ
Last week, I flagged the growing risk that tariffs could upend affordability in the generics market. This week, the Trump administration made it official: it’s launching national security investigations under Section 232 of the Trade...
Last week, I flagged the growing risk that tariffs could upend affordability in the generics market. This week, the Trump administration made it official: it’s launching national security investigations under Section 232 of the Trade...
Last week, I flagged the growing...
04/16/2025
First Report Managed Care
Behind the Bill
The Bitter Pill: How Tariffs Could Make Generics Less Affordable
04/09/2025
Katie Hayes, MJ
As President Donald Trump’s administration introduces a series of tariffs aimed at rebalancing trade and boosting US manufacturing, one sector in particular is watching closely: pharmaceuticals. While drugs themselves may not be directly...
As President Donald Trump’s administration introduces a series of tariffs aimed at rebalancing trade and boosting US manufacturing, one sector in particular is watching closely: pharmaceuticals. While drugs themselves may not be directly...
As President Donald Trump’s...
04/09/2025
First Report Managed Care
Behind the Bill
SCOTUS Takes on the Nondelegation Doctrine: Surprising Reactions and What They Mean for Agency Power
04/02/2025
Katie Hayes, MJ
The Supreme Court recently heard arguments in Federal Communication Commission (FCC) v Consumers’ Research, a case that I covered in February and one that could dramatically reshape federal agency authority through the nondelegation...
The Supreme Court recently heard arguments in Federal Communication Commission (FCC) v Consumers’ Research, a case that I covered in February and one that could dramatically reshape federal agency authority through the nondelegation...
The Supreme Court recently heard...
04/02/2025
First Report Managed Care
Behind the Bill
Dr Oz’s Prescription for Making Medicaid “Viable at Every Level”
03/26/2025
Katie Hayes, MJ
On Tuesday, March 25, 2025, the Senate Finance Committee voted to advance Dr Mehmet Oz in his confirmation as the next head of the Centers for Medicare and Medicaid Services (CMS).1 The full Senate vote is expected “soon” (whatever that...
On Tuesday, March 25, 2025, the Senate Finance Committee voted to advance Dr Mehmet Oz in his confirmation as the next head of the Centers for Medicare and Medicaid Services (CMS).1 The full Senate vote is expected “soon” (whatever that...
On Tuesday, March 25, 2025, the...
03/26/2025
First Report Managed Care
Behind the Bill
The $880 Billion Question Continues: Dr Oz's Confirmation and the Future of Medicaid
03/19/2025
Katie Hayes, MJ
Last week, I explored the $880 billion question facing Congress—whether lawmakers could achieve their budget goals without cutting Medicaid. This week, that question took center stage as Dr Mehmet Oz, President Trump's nominee to lead the...
Last week, I explored the $880 billion question facing Congress—whether lawmakers could achieve their budget goals without cutting Medicaid. This week, that question took center stage as Dr Mehmet Oz, President Trump's nominee to lead the...
Last week, I explored the $880...
03/19/2025
First Report Managed Care
Behind the Bill
The $880 Billion Question: Can Congress Cut Spending Without Touching Medicaid?
03/12/2025
Katie Hayes, MJ
I’d like to step away from administrative law for a moment to provide a quick update on Medicaid. With news coming from all sides, what does the future of Medicaid actually look like? The House of Representatives narrowly passed a budget...
I’d like to step away from administrative law for a moment to provide a quick update on Medicaid. With news coming from all sides, what does the future of Medicaid actually look like? The House of Representatives narrowly passed a budget...
I’d like to step away from...
03/12/2025
First Report Managed Care
Behind the Bill
RFK Jr’s Public Comment Ban: The Silent Shift in Health Care Rulemaking
03/05/2025
Katie Hayes, MJ
The erosion of administrative law continues, and with it, the dismantling of decades-long precedent. In June, the Supreme Court overturned a 40-year-old doctrine that allowed federal agencies to interpret their own ambiguous statutes. Later...
The erosion of administrative law continues, and with it, the dismantling of decades-long precedent. In June, the Supreme Court overturned a 40-year-old doctrine that allowed federal agencies to interpret their own ambiguous statutes. Later...
The erosion of administrative...
03/05/2025
First Report Managed Care
Behind the Bill
Prevention Over Pills? The First 2 Weeks of Health Care’s New Direction
02/26/2025
Katie Hayes, MJ
The dust has barely settled from Robert F Kennedy Jr’s confirmation as Secretary of Health and Human Services (HHS), but the changes are already coming fast and furious—a key theme of the Trump Administration’s actions within the last several...
The dust has barely settled from Robert F Kennedy Jr’s confirmation as Secretary of Health and Human Services (HHS), but the changes are already coming fast and furious—a key theme of the Trump Administration’s actions within the last several...
The dust has barely settled from...
02/26/2025
First Report Managed Care
Behind the Bill
The Nondelegation Doctrine: The Next Constitutional Showdown (Part 2)
02/19/2025
Katie Hayes, MJ
Last week, I explored the potential revival of the nondelegation doctrine through Federal Communication Commission v Consumers’ Research. Today, I want to examine what this could mean for health care regulation by considering the parallels...
Last week, I explored the potential revival of the nondelegation doctrine through Federal Communication Commission v Consumers’ Research. Today, I want to examine what this could mean for health care regulation by considering the parallels...
Last week, I explored the...
02/19/2025
First Report Managed Care

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Examining the Benefits of County-Based Public Insurance in California
05/26/2023
Julie Gould
Researchers studied the impact of county-based public insurance on premium growth in California's Affordable Care Act exchange.
Researchers studied the impact of county-based public insurance on premium growth in California's Affordable Care Act exchange.
Researchers studied the impact...
05/26/2023
First Report Managed Care
News
Ceralasertib Alone Shows Little Benefit for Relapsed/Refractory CLL
06/22/2023
Jolynn Tumolo
For the study, patients who were heavily pretreated for chronic lymphocytic leukemia received ceralasertib with vs without acalabrutinib.
For the study, patients who were heavily pretreated for chronic lymphocytic leukemia received ceralasertib with vs without acalabrutinib.
For the study, patients who were...
06/22/2023
First Report Managed Care
News
High Industry Payments to Hemophilia Center Directors May Be Cause for Concern
07/21/2023
Jolynn Tumolo
“Future studies should assess whether high payments, especially among individuals who have responsibility over the success of hemophilia centers and clinics, may result in competition with the interest of the patients at these centers and...
“Future studies should assess whether high payments, especially among individuals who have responsibility over the success of hemophilia centers and clinics, may result in competition with the interest of the patients at these centers and...
“Future studies should assess...
07/21/2023
First Report Managed Care
News
Proposed Rule Would Make Hospital Prices Even More Transparent
08/14/2023
Julie Appleby
Although government data shows that hospitals’ compliance with price transparency rules has improved, updating the requirements of that law is the focus of a new proposal that aims further standardize the required data, increase its...
Although government data shows that hospitals’ compliance with price transparency rules has improved, updating the requirements of that law is the focus of a new proposal that aims further standardize the required data, increase its...
Although government data shows...
08/14/2023
First Report Managed Care
News
Ongoing Study of IL-23 in Asthma May Yield More Treatment Options
09/11/2023
Jolynn Tumolo
A new study suggests that gaining a better understanding of the relationship between interleukin (IL)-23 and airway inflammation in asthma patients could lead to alternative treatment options beyond traditional anti-type 2 inflammatory...
A new study suggests that gaining a better understanding of the relationship between interleukin (IL)-23 and airway inflammation in asthma patients could lead to alternative treatment options beyond traditional anti-type 2 inflammatory...
A new study suggests that...
09/11/2023
First Report Managed Care

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